2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide
ML365
CAS: 947914-18-3
Molecular Formula: C22H20N2O3
2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide - Names and Identifiers
2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide - Physico-chemical Properties
| Molecular Formula | C22H20N2O3 |
| Molar Mass | 360.41 |
| Density | 1.253±0.06 g/cm3(Predicted) |
| Boling Point | 429.9±40.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 13.21±0.70(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC 50 = 4 nM) and an automated electrophysiology assay (IC 50 = 16 nM). ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). ML365 does not exhibit acute toxicity in cell-based assays at concentrations up to 30 μM. |
2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.775 ml | 13.873 ml | 27.747 ml |
| 5 mM | 0.555 ml | 2.775 ml | 5.549 ml |
| 10 mM | 0.277 ml | 1.387 ml | 2.775 ml |
| 5 mM | 0.055 ml | 0.277 ml | 0.555 ml |
Last Update：2024-01-02 23:10:35
2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide - Reference Information
| biological activity | ML365 is a novel small molecule inhibitor of TASK1 or KCNK3. |
| Target | TargetValue TASK1/KCNK3 () |
| Target | Value |
| in vitro study | ML365 blocks TASK1 channels in and an automated electrophysiology assay (IC 50=16 nM). ML365 displays little or no inhibition at 30 μm of more different related pot channels, Kir2.1, pot voltage-gated channel, KQT-like subffamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). ML365 does not exhibit acute toxicity in cell-based assays at concentrations up to 30 μM. |
Last Update：2024-04-09 20:52:54
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Product Name: ML365 Visit Supplier Webpage Request for quotationCAS: 947914-18-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: ML365 Visit Supplier Webpage Request for quotationCAS: 947914-18-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
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Product Name: ML365 Visit Supplier Webpage Request for quotationCAS: 947914-18-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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